Christian A Hassig Selected Research

4- ((2- cyclobutyl- 1H- imidazo(4,5- b)pyrazin- 1- yl)methyl)- 7,8- difluoroquinolin- 2(1H)- one

2/2011	Pharmacological characterization of KLYP961, a dual inhibitor of inducible and neuronal nitric-oxide synthases.
11/2010	Discovery of dual inducible/neuronal nitric oxide synthase (iNOS/nNOS) inhibitor development candidate 4-((2-cyclobutyl-1H-imidazo[4,5-b]pyrazin-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one (KD7332) part 2: identification of a novel, potent, and selective series of benzimidazole-quinolinone iNOS/nNOS dimerization inhibitors that are orally active in pain models.
5/2009	Discovery of inducible nitric oxide synthase (iNOS) inhibitor development candidate KD7332, part 1: Identification of a novel, potent, and selective series of quinolinone iNOS dimerization inhibitors that are orally active in rodent pain models.

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Christian A Hassig Research Topics

Disease

8	Neoplasms (Cancer) 01/2021 - 05/2008
5	Pain (Aches) 11/2011 - 05/2009
2	Melanoma (Melanoma, Malignant) 12/2015 - 05/2013
2	Hyperalgesia 11/2011 - 02/2011
2	Neuralgia (Stump Neuralgia) 11/2010 - 05/2009
1	Heart Failure 01/2016
1	Skin Neoplasms (Skin Cancer) 05/2013
1	Inflammation (Inflammations) 01/2012
1	Edema (Dropsy) 02/2011
1	Endotoxemia 07/2009
1	Cutaneous T-Cell Lymphoma (Lymphoma, T Cell, Cutaneous) 05/2008
1	Prostatic Neoplasms (Prostate Cancer) 05/2008

Drug/Important Bio-Agent (IBA)

4	Formaldehyde (Formol)FDA Link 02/2011 - 05/2009
3	4- ((2- cyclobutyl- 1H- imidazo(4,5- b)pyrazin- 1- yl)methyl)- 7,8- difluoroquinolin- 2(1H)- oneIBA 02/2011 - 05/2009
3	KD 5170IBA 12/2008 - 05/2008
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2012 - 02/2011
2	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 02/2011 - 05/2009
2	Nitric Oxide Synthase Type I (Neuronal Nitric Oxide Synthase)IBA 02/2011 - 11/2010
2	QuinolonesIBA 11/2010 - 05/2009
2	Histone Deacetylase InhibitorsIBA 12/2008 - 05/2008
2	Histones (Histone)IBA 12/2008 - 06/2008
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 01/2021
1	Gemcitabine FDA Link 12/2019
1	B7-H1 AntigenIBA 12/2019
1	Immune Checkpoint InhibitorsIBA 12/2019
1	SRA737IBA 12/2019
1	Arsenic Trioxide (Trisenox)FDA Link 01/2016
1	Promyelocytic Leukemia ProteinIBA 01/2016
1	Adenosine Triphosphatases (ATPase)IBA 01/2016
1	Cardiac GlycosidesIBA 01/2016
1	CeramidesIBA 01/2016
1	Eukaryotic Initiation Factor-4F (EIF4F)IBA 12/2015
1	SBI-0640756IBA 12/2015
1	Peptide Initiation Factors (Initiation Factor)IBA 12/2015
1	Pharmaceutical PreparationsIBA 12/2015
1	Proteins (Proteins, Gene)FDA Link 09/2014
1	Caspase 3 (Caspase-3)IBA 09/2014
1	Threonine (L-Threonine)FDA Link 05/2013
1	Activating Transcription Factor 2IBA 05/2013
1	Doxycycline (Periostat)FDA LinkGeneric 05/2013
1	EnzymesIBA 01/2012
1	Biological ProductsIBA 01/2012
1	Nitric Oxide Synthase (NO Synthase)IBA 01/2012
1	imidazoleIBA 11/2011
1	Gabapentin (Neurontin)FDA LinkGeneric 02/2011
1	Pregabalin (Lyrica)FDA Link 02/2011
1	Capsaicin (Zostrix)FDA Link 02/2011
1	Duloxetine Hydrochloride (Cymbalta)FDA Link 02/2011
1	Celecoxib (Celebrex)FDA Link 02/2011
1	CarrageenanIBA 02/2011
1	phenylbenzoquinoneIBA 02/2011
1	benzimidazoleIBA 11/2010
1	N- (3- chlorophenyl)- N- ((8- fluoro- 2- oxo- 1,2- dihydroquinolin- 4- yl)methyl)- 4- methylthiazole- 5- carboxamideIBA 07/2009
1	Vorinostat FDA Link 05/2008
1	Docetaxel (Taxotere)FDA Link 05/2008
1	Histone Deacetylases (Histone Deacetylase)IBA 05/2008

Therapy/Procedure

2	Therapeutics 12/2015 - 05/2013
2	Ligation 11/2011 - 02/2011
1	Immunotherapy 12/2019
1	Drug Therapy (Chemotherapy) 12/2019
1	Oral Administration 07/2009